Box Plot from Scientific Research

BA17 (primary visual cortex) was associated with higher levels of synapsin 1 colocalization inside CD68-positive microglia compared with BA20/21 (inferior temporal cortex) (F[1,1973.76] = 67.82, p = 3.42 x 10-16). Statistical comparisons were made using post hoc Tukey test or ANOVA after linear mixed effects model on Tukey transformed data with case as a random effect and disease, brain region,APOE4status, gender, and age as fixed effects. Untransformed data are presented in graphs (B)–(E). Males are represented by circles and females by triangles. Biological replicates were human brain donors: n = 10 midlife controls, 17 aged controls, AD 22 cases.

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