Microscopy from Scientific Research

Confocal images of immunostaining with orthogonal views (left) and three-dimensional reconstructions of stacks (right) of midlife control, aged control, and Alzheimer’s disease showing ingestion of synapsin 1 (Syn1, green) by astrocytes (GFAP, magenta) in human brain sections. A plaques and nuclei are counterstained with Thioflavin S and DAPI, respectively, shown in blue. Only ingested Syn1 is shown in 3D Imaris reconstructions. Representative images are from BA17. Scale bars represent 5 m.

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