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Schematic depiction of cell-cycle-dependent activity of DLL/NOTCH and WNT/β-catenin signaling in neuroectoderm progenitors, which can create cell-cycle-dependent field effects through secreted WNTs and spatiotemporal effects on neuroepithelial versus neural crest specification. All data are shown as mean ± SD (n = 3). Statistical analysis was performed by two-way ANOVA with multiple comparisons with Tukey correction;∗∗∗∗padjusted< 0.0001,∗∗∗padjusted< 0.001,∗∗padjusted< 0.01,∗padjusted< 0.05.

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