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Low cADPR basal levels appear in all hSARM1 transfected cells, including the gain-of-function mutants and the hSARM1E642QNADase-dead mutant. ceTIR-1 produces high levels of cADPR, 15x more than the basal level. Even the ceTIR-1N827Aloss-of-function mutant produces about 4x more.
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