Violin Plot from Scientific Research

Effect of single-copy LoF mutations within effector genes and set-point genes. Glycated hemoglobin (HbA1c, baseline level 35 mmol/mol) measures of individuals in UK Biobank with single functional copies (due to LoF mutations) of effectors, intermediate effectors, and set-point genes. HbA1c reflects long-term blood glucose levels; other glycemic measures exhibit similar patterns (as shown in Figure S7). Association p value of LoF variants with a phenotype was evaluated by linear regression considering sex and age as covariates.

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