Stacked Bar Plot from Scientific Research

DNA vs. RNA metrics at 16,448 autosomal protein-coding genes. RNA metrics (aFC, allelic fold change induced bycis-regulatory variants) are calculated in tissues from GTEx; larger aFC indicates more dosage tolerant. For the RNA metric, the aFC in each direction (dosage increase or decrease, direction is with respect to reference allele of acis-regulatory variant) is shown in left and right panels. For each gene, we take the maximum aFC (by effect size |aFC|) across tissues (median aFC across tissues are shown inFigureS2). The DNA metric is the degree of depletion of LoF variants asmeasured by observed/expected upper bound fraction (LOEUF) from gnomAD. Smaller LOEUF indicates higher dosage constraint.

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