Bar Plot from Scientific Research

Tail immersion experiment in cre.neg (WT, black) and cre.pos (Nav1.7 KO, red) ERT.cre; fl/fl Nav1.7 mice measured 6-8 weeks after tamoxifen dosing. Naloxone injection did not reverse the analgesia observed in Nav1.7 KO mice (n = 22 mice per group, two-way ANOVA, non-significant), while naloxone reversed morphine-induced analgesia in the same model (right, n = 10 mice per group, one-way ANOVA with Sidak’s multiple comparisons test; p < 0.001 baseline vs. post-morphine; p < 0.001 post-morphine vs. post naloxone).

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