Schematic ofFigure 6. Plasma TNF (B, G, H, M, N, S, V, and AA), spleen and liver MPO (C, I, O, and W), plasma alanine transaminase (ALT) (D, J, P, and X), body weight (E, K, Q, and Y), muscle weight (F, L, R, and Z), and brain TNF (G, M, S, and AA) in WT andAlb-/-mice. (T) NOD2-dependent SEAP production by HEK293 cells stimulated with plasma from WT andAlb-/-mice. (U) Reaction norm plot of body weight of mice administered Firmicutes PG versus NOD2-dependent SEAP production by HEK293 stimulated with plasma from the same mice. Data are relative to WT mice without a microbiota treated with isotype control antibodies (B, D, E, H, J, K, N, P, Q, X, and Y). Data are relative to WT mice with a microbiota treated with isotype control antibodies (C, F, G, I, L, M, O, R, S, W, Z, and AA). Error bars are mean +/- SD. Comparisons were by one-way ANOVA with Sidak’s or t test for all, except (W) compared by analysis of covariance (ANCOVA);*p < 0.05,**p < 0.01, and***p < 0.001.
