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Age-altered proteins grouped by cellular localization (GO cellular component). Protein count in brackets. Anti-longevity (purple) and pro-longevity (green) genes indicated. Top three biological processes listed. Refer toTable S1for detailed protein lists. Statistical significance in (B) was assessed unpaired t test with Welch correction and Fisher’s exact test in (D)–(G). Effect size in (B) is displayed as common language effect size (CLES) and in (D)–(G) as odds ratio (OR).**p < 0.01;****p < 0.0001. See alsoFigure S1andTable S1.

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