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Schematics of OPTN (pink) and NEMO (green); UBAN domains are highlighted with gold stripes. UBAN sequences of OPTN (pink) and NEMO (green) were aligned with NCBI BLAST. Small letters indicate exact matches. "+" indicates residues with chemical similarity. Right, PDB pairwise structure alignment using jFATCAT (flexible) alignment between the UBAN domains of dimerized OPTN (PDB:5WQ4) (pink) and NEMO (PDB:3JSV) (green), and their interactions with K63-linked di-ubiquitin (gray). CC1/2, coiled-coil domains; LIR, LC3 interacting region; ZnF, zinc-finger domain; HLX1, helical domain.

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