Protein Structure from Scientific Research

Comparison of the cytokine binding mode of the TPO-2xMPL complex with the EPO-2xEpoR complex. The alpha helices (A–D) are shown as cylinders for TPO (salmon) and EPO (red). Loops 1–6 (L1–L6) of MPL are indicated in the panel, where the extremely long L5 is mostly unresolved in the structure. The black arrows indicate the linker between D1 and D2 of MPL.

DOI