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RREB1 (RAS-responsive element binding protein 1) links the TGF--SMAD and RAS-MARK pathways to coordinate the expression of developmental and fibrogenic EMT programs. MAPK-activated RREB1 is preloaded on loci including EMT-TF genes and either mesendoderm specification genes in epiblast cells or fibrogenic genes in adult epithelial progenitors and adenocarcinoma cells. DNA-bound RREB1 then enables TGF- receptor-activated SMADs to drive expression of these genes to trigger developmental or fibrogenic EMTs, respectively.
#Workflow#Illustration#RREB1#RAS-responsive element binding protein 1#TGF-beta-SMAD Pathway#RAS-MARK Pathway#EMT Programs#MAPK#EMT-TF Genes#Mesendoderm Specification Genes#Epiblast Cells#Fibrogenic Genes#Epithelial Progenitors#Adenocarcinoma Cells#SMADs
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