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High myopia modeling increased the spine density of BLA pyramidal neurons and decreased the spine density of ventral hippocampus neurons, which were partially reversed by Ccl2 deficiency. Data are mean SD. n = 12 in each group ( a , b ); n = 4 in each group ( c , d ) . The level of significance was detected with Student’s t- test ( a , b ) or one-way ANOVA ( d ). **** P < 0.0001, ***P < 0.001, **P < 0.01, * P < 0.05, ns P > 0.05.

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