Deviation from expected age dependence for each mCA observed ≥30 times in men and ≥30 times in women, with examples from each mCA class. Red, gains; blue, losses; yellow, CN-LOH events. Darker shade, men; lighter shade, women (see Supplementary Figs. 15 – 17 for age dependence plots for all mCAs). Deviation from expected age dependence was calculated as the relative difference between the observed and expected age dependence gradients. Positive deviation reflects mCAs that show a greater increase in prevalence with age than expected. Negative deviation reflects mCAs that show less increase in prevalence with age than expected. mCAs whose deviation was statistically significant ( P < 0.05) are highlighted with an asterisk (see Supplementary Note 2 and Supplementary Table 3 ).
