Fold differences in fitness effects ( s ) and mutation rates ( μ ) between men and women for gains (red), losses (blue) and CN-LOH (yellow) events that were observed as a single mCA ≥10 times in men and in women and which showed a significant difference in either fitness effect or mutation rate. n w and n m , number of times each mCA was observed in women and men, respectively. Error bars represent the 95% confidence intervals from the distribution of fold difference between men and women. Upper 95% confidence intervals > 150 (see Supplementary Table 2 ) are indicated by arrows. Data points with no black border and whose fold difference values are in grey indicate mCAs whose fitness effect or mutation rate was not significantly different between men and women.
