Line Plot from Scientific Research

Plotting all cell fraction measurements for a particular mCA (for example, 14q+, n = 147 observations) as log-binned histograms yields estimates for s (mCA fitness effect) and Nτμ (product of the mutation rate, μ , and the stem cell population size multiplied by the symmetric cell division time in years, Nτ ). Using an estimate for Nτ of ~ 100,000 allows the mCA-specific mutation rate to be calculated. Using the known distribution of ages in UK Biobank enables s to be calculated. Data points are presented as mean values ± s.e.m.

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