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Total clonal (CCF ≥ 0.75) mutations per Mb in 16- to 20-week Msh2 KO autochthonous lung tumors ( Msh2 flox - and sgMsh2-targeted models) from animals with no treatment (light blue, n = 41), continuous antibody-mediated T cell depletion (αCD4/8, magenta, n = 34) and 4 weeks of ICB (αPD-1/αCTLA-4, gray, n = 12).
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