gLink approach 2, quantifying AREgene linking based on shared genetic regulation. Top, a schematic view of the approach. Middle, solid dots denote the gAREs linked to MADCAM1 supported by different scores (by row) in different colors; gLink scores are grouped by two approaches with label on the left; the gARE labeled by black dashed vertical line (right one) is supported by scores from both approaches; the ARE labeled by green dashed vertical line (left one) is supported by scores only from approach 2. Bottom, correlation of polygenic gene expression of MADCAM1 ( y axis) and activity of the ARE only captured by scores from approach 2 ( x axis) across individuals, with r 2 and P value (twosided based on linear regression) labeled, and regression line (solid red) and its 95% confidence interval (dashed blue) shown.
