Bar Plot from Scientific Research

Mean GLP1R variant mini-Gs coupling and receptor endocytosis, with surface expression correction, in response to GLP-1, OXM, glucagon (GCG), exendin-4 (Ex4), semaglutide (Sema) and tirzepatide (TZP), n = 6. Positive deviation indicates variant gain-of-function, with statistical significance inferred when the 95% CIs shown do not cross zero. Responses are also compared between pathways by unpaired t test, with an asterisk indicating statistically significant differences.

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