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Clonal evolution of TP53-mutant CP patient samples without clinical evidence of transformation (CP-TP53-MPN, n = 4) and pre-TP53-sAML (patients who subsequently transformed to TP53-sAML) samples (n = 5). The size of the circles is proportional to the average percentage of cells mapping to each clone, and each clone is colored according to its genotype (related to Extended Data Fig. 9e–m). TP53-heterozygous cells selected for subsequent transcriptional analysis are indicated by the blue box.

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