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Representative examples of the four major patterns of clonal evolution in TP53 -sAML patients: bi-allelic mutations. The numbers in parenthesis indicate the number of patients in each category. The size of the circles is proportional to each clone’s size, indicated as a percentage of total Lin - CD34 + cells for one representative patient in each group; each clone is colored according to its genotype (related to Extended Data Fig. 2b–o ) and red boxes indicate TP53 multihit clones.

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