Mean cell scores per patient in positive (>0.001) CD8 + T cells (e) or macrophages (f) for the tumor reactivity factor (e) and the macrophage invasion factor (f) based on smoking (top) or EGFR mutation (bottom) status. P values were calculated using Mann–Whitney U -tests (two-sided); tumor reactivity smoking: n = 153, P = 0.0022, statistic = 3,500, Cohen’s d = 0.45; tumor reactivity EGFR : n = 30, P = 0.18, statistic = 78, Cohen’s d = 0.52; invasion smoking: n = 147, P = 0.051, statistic = 2,928, Cohen’s d = 0.30; invasion EGFR : n = 32, P = 0.010, statistic = 59, Cohen’s d = 1.17). Boxes and lines represent IQR and median, respectively; whiskers represent 1.5 IQR.
