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Activin/nodal/TGF and BMP spectra factor scores across control, OE and OE-high cells (top) and control, KD and KD-high cells (bottom). Mean scores are normalized relative to controls. OE-high cells: subset of OE cells with above average Zfp281 expression. KD-high cells: subset of KD cells with below average Zfp281 expression (MannWhitneyWilcoxon test, twosided; **** P < 0.0001; *** P < 0.001; ** P < 0.01; NS = P > 0.05).
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