Line Plot from Scientific Research

Top, accessibility browser tracks for each lineage split by day, highlighting peaks linked to late lineage markers (on-target: Aox3 ; off-target: Col28a1 and Vegfd ) showing lineage-specific changes in accessibility on day 3. The Aox3 - and Vegfd -linked DERs overlap perfectly with an ENCODE Enhancer-Like Signature (ELS) element, while the Col28a1 -linked DER is within 100 bp of an ELS. Bottom, expression levels of the three genes across MEFs and the two reprogramming lineages split by days (MannWhitneyWilcoxon test; two-sided; Bonferroni corrected **** P < 0.0001).

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