Microbe–microbe co-occurrence and mutual exclusivity across 1,194 signatures of fecal microbiomes from 311 published studies. 'Abundance in group 1' shows the top 20 genera most frequently reported as differentially abundant in the study group of these signatures. Stars indicate microbes that tend to be predominantly unidirectional, that is, reported specifically with increased or decreased abundance in the study group (based on a greater than twofold difference in proportions). 'Prevalence' shows the prevalence of these genera in 9,623 healthy adult stool samples pooled from 68 different studies. The top heat map shows co-occurrence between these top 20 genera, that is, in how many signatures these microbes are reported together as differentially abundant with the same direction of abundance change (that is, occurring together in either the signature of increased or decreased abundance). The bottom heat map shows mutual exclusivity between these top 20 genera, that is, in how many signatures these microbes are reported as differentially abundant with opposite direction of abundance change (that is, one microbe in the signature of increased abundance and the other in the signature of decreased abundance or vice versa).
