Bubble Plot from Scientific Research

ORA of BugSigDB signatures with differentially abundant genera between 662 colorectal cancer samples and 653 control samples pooled from ten published metagenomic datasets. Each dot corresponds to an enriched published signature from BugSigDB (false discovery rate P value ( P adj ) of <0.05, one-sided Fisher’s exact test, color scale). The size of each dot corresponds to the number of differentially abundant genera in a signature, given as a proportion on the x axis. Asterisks (*) indicate prior meta-analytic signatures from Thomas et al. 56 and Wirbel et al. 57 , which reported differentially abundant species and genera from meta-analysis of eight colorectal cancer datasets. These act as positive controls, as several of the datasets being tested for enrichment were included at the time these signatures were derived.

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