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Average-linkage cluster heatmap for each method on bin number 2328 from Pasolli et al. 1 (classified as Alistipes ihumii ) with 195 genomes. Cophenetic correlation (CP) of each method’s dendrogram (with ANIm’s distance matrix as a ground truth) is shown. skani’s high cophenetic correlation indicates that its dendrogram is concordant with ANIm’s dendrogram, which we show in Extended Data Fig. 2 . The Robinson-Foulds distances 23 for skani, FastANI and Mash’s dendrograms against ANIm’s average-linkage tree are 0.489, 0.713 and 0.823, respectively.
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