Workflow from Scientific Research
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Saturating concentrations of ATP-competitive PERK inhibitor (PERKi) occupy both ATP-pockets and inhibit GCN2 whilst sub-saturating concentrations of PERKi result in occupancy of one of the two ATP-binding sites of the GCN2 dimer and kinase activation. Source data are provided as a Source data file.
#Workflow#Illustration#ATP-competitive PERK Inhibitor#ATP-pockets#GCN2#ATP-binding Sites#GCN2 Dimer#Kinase Activation
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