Shown is the fold change from baseline to maximum response in the ex vivo FluoroSpot assay or ICS assay for T cell responders (n = 21/25 patients). T cell responders are defined as patients having a >=2-fold increase from baseline at any post-vaccination timepoint (dotted line) and >50 SFCs/1 x 106 PBMCs for FluoroSpot assay or >0.1% cytokine-positive for ICS assay. The median fold change is shown at 12.75, indicated by a dashed line. * Patients without baseline-detectable T cell responses (below the response threshold) had on-treatment fold change of 348x, 58.3x, 20.7x, 18.3x, 9.7x, 3.7x and 2.1x.
