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Two clusters without annotations were found with structural similarity to a cluster enriched for the gasdermin Pfam annotations. Cluster 2 gasdermin N-terminal domain structures reveal homology to human gasdermin E. The corresponding structural characteristics are highlighted. Some gasdermin domains were found fused to protease domains (UniProt: A0A2C5ZLK3 ). The bacterial gasdermin structure (PDB: 7N51 ) is similar to novel gasdermin domains from non-annotated cluster 2. The third cluster revealed homology to both animal and bacterial gasdermins.
#Network#Protein Structure#Gasdermin Pfam Annotations#Structural Similarity#Gasdermin N-terminal Domain#Human Gasdermin E#Protease Domains#Bacterial Gasdermin
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