Box Plot from Scientific Research

Cryptic HDGFL2 CSF:diluent MSD signal ratios measured in CSF of healthy controls (n = 16), migraine controls (n = 25), NPH controls (n = 25), presymptomatic (n = 81) and symptomatic (n = 76) C9orf72 mutation carriers, and sporadic ALS (n = 44). Values and statistics are shown in Extended Data Table 1. Ratios >1 indicate elevated signal. Data presented as mean s.d. Data points represent individuals with longitudinal CSF measurements averaged as applicable. MannWhitney U -test with HolmBonferroni correction, * P 0.05, ** P 0.01, *** P 0.001, **** P 0.0001.

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