Comparison of WT (left) and cryptic (right) HDGFL2 protein structures. Inclusion of the cryptic exon in mRNA leads to the addition of 46 amino acids predicted to form an alpha-helix structure (red) between flanking unstructured regions. Both structures are generated using AlphaFold predictions derived from amino acid sequences. The WT HDGFL2 protein structure can be found on the AlphaFold protein structure database (UniProt: Q7Z4V5).
