The SHIELD program comprised three stages. In stage I (July 2015May 2018), which was a pilot stage to develop a management algorithm and tool for preventing HBV MTCT for stage II, 1,008 HBsAg-positive pregnant women at ten hospitals nationwide were voluntarily enrolled. In stage II (July 2015December 2025), which was an implementation stage to apply the management algorithm and tool for preventing HBV MTCT from stage I in member hospitals across China, HBsAg-positive pregnant women at 178 hospitals nationwide were voluntarily enrolled. In stage III (January 2018December 2019), the program was scaled up and implemented in all community health centers and hospitals in the Baoan district of Shenzhen, China. One-stop services were especially established in Baoan district to implement the intervention package for all pregnant women with HBV infection from 18 hospitals and 142 community health centers. PI, principal investigator.
