Protein Structure from Scientific Research

Structural modeling supports C15orf41, CDAN1, ASF1A, and HIRA participating in a large multiprotein complex. Using AlphaFold-multimer, we find that all four proteins can be simultaneously accommodated within a single multiprotein complex, here showing C15orf41s modeled interaction with CDAN1 residues 2-74 and 286-1203, ASF1A residues 1-155, and HIRA residues 421-479. For illustration purposes, the known crystal structure of HIRA 446-466 [ 56 ] has been superimposed onto the AlphaFold model, which is available in full from the supporting GitHub repository with accompanying quality measurements

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