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The WAVE1/WAVE2 protein complexes, known to regulate actin filament and lamellipodia formation [ 32 , 33 ], are reconstructed by RL, along with evidence for interaction with the uncharacterized protein KIAA1522. Notably, KIAA1522 was recently suggested by Cho and colleagues to bind WAVE and participate in a community of associated actin-organizing proteins [ 34 ]

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