Simple two-tailed linear regression of percentage liver burden inhibitory activity compared with untreated, infected mice (geometric mean, n = 5) and normalized to the activity of AB-000317, with each mAb indicated as having activity either significantly better (gray upward-pointing triangle), not different to (cyan circles) or weaker than (orange downward-pointing triangles) AB-000317 (two-tailed, nonparametric log-rank) versus the number of amino acid changes from germline (SHM) for each mAb ( n = 69)heavy (see Extended Data Table 1 for correlation analyses of non-log-transformed data).
