SPR-determined binding potencies (K d ) of mAbs (n = 141) selected from 35 of the most efficacious lineages tested against CSP and a panel of CSP-derived peptides that are either homologous (NANP6, NPNA3) or heterologous (NVDP3NANP2, NPDPNANPNVDPNANP, junction [KQPADGNPDPNANPN]) to RTS,S. Examples are shown of a mAb with a broadly promiscuous binding profile (green, AB-007163), another with a profile relatively biased toward homologous peptides (purple, AB-007143) and a third with a profile between these extremes (blue, AB-007175).
