KaplanMeier estimates of overall survival with P values calculated using a stratified log-rank test. The numbers of patients at risk at different time points are indicated below the survival curves. Points and error bars on the embedded forest plots indicate HRs with 95% CIs, correspondingly. HRs, CIs and P values were calculated from Cox proportional-hazards models corrected according to cancer stage. Patients were stratified according to the mutational status of genes indicated for testing in NGTDC across all cancer types ( n =11,337). Exact P values can be found in Supplementary Table 2.
