The proportion of human MIBC cases [ 22 ] ( n = 412) with somatic mutations in COSMIC Cancer Gene Census genes that have a one-to-one orthologous relationship with both a canine and a feline gene. Shown are mutations present in 4 or more canine or feline samples, which are prefixed with DD and CATD, respectively. Also shown are canine samples with MDM2 amplification, which is shown in the same row as TP53 mutations, to enable visual comparison with feline and human TP53 mutations. CDKN2A has not been included, as, although the feline cohort had 4 samples with CDKN2A mutations, Ensembl does not classify the human and feline genes as orthologs, and, in canines, human CDKN2B is designated an ortholog of canine CDKN2A .
