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Ability to separate genes classified as pan-dependencies in both CRISPR datasets ( N = 1339) from genes that were not pan-dependencies in either CRISPR dataset ( N = 14,702) using ROC AUC of mean gene trap results for KBM7 and HAP1 (AUC = 0.96), RNAi mean D2-Combined gene effect (AUC = 0.86), and the median of ExAC constrained loss-of-function metrics (AUC = 0.65)
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