Illustration from Scientific Research

A proposed model for the impacts of MYC2 in 3D genome organization and gene transcription. In the MYC2 dominated chromatin hub, MYC2 coupled with other TFs and mediators to create microenvironment that facilitates gene transcription in the wild-type. As MYC2 activity is abolished, the MYC2-centric hub is disassembled and the gene expression decreases. More red wavy lines indicate higher expression

DOI