TMB (number of nonsynonymous mutations per megabase of protein coding genome, y axis, log 10 scale) in nonresponders (NR, n = 5) versus responders (R, n = 14). Blue stars indicate patients with dMMR tumors. Box plots represent the median, 25th and 75th percentiles; whiskers extend from the hinge to the largest value below 1.5x IQR from the hinge. The difference between NR and R was tested using a two-sided Wilcoxon rank-sum test.
