UMAP visualization of healthy human hematopoietic cells ( n = 155,574 cells), with each dot representing a cell and colors indicating distinct cell types. The inset plot provides an enlarged view of the six HSPC clusters, including HSC (hematopoietic stem cell), LMPP (lymphoid-primed multi-potential progenitor), GMP (granulocyte-macrophage progenitor), CLP (common lymphoid progenitor), MEP (megakaryocyte (MK) and erythroid progenitor), and E/B/M (eosinophil/basophil/mast cell progenitor) that express three lineages-specific canonical markers and MEP commitment-essential transcription factors, consistent with previous reports [ 14 , 15 , 16 , 17 ].
