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Cell-cell interactions were defined by NicheNetr. Ligands expressed by BMMNCs were ranked by likelihood that ligands would affect gene expression changes in CD34+HSPCs. Receptors expressed on CD34+HSPCs were selected based on their known potentials to interact with prioritized ligands. Finally, target genes were selected based on their differential expression in CD34+HSPCs and their potentials to be regulated by ligand-receptor interactions identified between BMMNCs and CD34+HSPCs.

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