Scatter Plot from Scientific Research

22B3 reduces skin inflammation in the imiquimod-induced mouse model of psoriasis. (Left) H&E histology of skin samples from a 22B3-treated mouse and an hIgG4-PAA isotype-treated control mouse. 22B3 was injected intraperitoneally (i.p.) at a dose of 3 mg/kg. Skin samples were obtained at day 4 post-antibody treatment. Epidermal thickness, defined as the distance between the basement membrane and the base of the cornified layer of the skin, is indicated by arrows. (Right) Each data point is the mean of the epidermal thickness in a single animal averaged over 10 measurements. Ten mice were used in each treatment group. Statistical analysis was performed using unpaired two-tailed Welch’s t test. Differences were considered significant at p <0.05.

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