cTWAS results at the HPR locus. Top, -log 10 P value of variants from GWAS and genes from TWAS. Each square represents a gene with position determined by its transcription start site. Each circle represents a variant. Colors indicate LD between the focal gene (orange) and nearby genes and variants: high LD (purple; R 2 > 0.4) and low LD (green, R 2 ≤ 0.4). The red dotted line indicates the transcriptome-wide significance threshold for TWAS (Bonferroni-corrected P < 0.05). The middle track represents the positions of the eQTL for the focal gene. Bottom: cTWAS PIPs for variants and genes at this locus.
