Enrichments and depletions of somatic mutations within CTCF binding sites. Heatmaps display only mutational signatures and cancer types that have at least one statistically significant enrichment or depletion of somatic mutations attributed to signatures of either SBSs, DBSs, or small IDs. Red colors correspond to enrichments of real somatic mutations when compared to simulated data. Blue colors correspond to depletions of real somatic mutations when compared to simulated data. The intensities of red and blue colors reflect the degree of enrichments or depletions based on the fold change. White colors correspond to lack of data for performing statistical comparisons (e.g., signature not being detected in a cancer type). Statistically significant enrichments and depletions are annotated with an asterisk (*; adjusted p value <= 0.05, z-test combined with Fisher’s method and corrected for multiple testing using Benjamini-Hochberg).
