The top three panels reflect average CTCF occupancy signal for all SBSs, DBS, and IDs across all examined cancer types. Bottom panels reflect all somatic mutations attributed for several exemplar mutational signatures across all cancer types. In all cases, solid lines correspond to real somatic mutations, with blue solid lines reflecting SBSs, red solid lines reflecting DBSs, and green solid lines reflecting IDs. Solid lines and dashed lines display the average CTCF binding signal (y axes) along a 2 kb window (x axes) centered at the mutation start site for real and simulated mutations, respectively. The mutation start site is annotated in the middle of each plot and denoted as 0. The 2 kb window encompasses 1,000 base pairs 5' adjacent to each mutation as well as 1,000 base pairs 3' adjacent to each mutation.
