Cone-driven ERG b-wave flash sensitivity (Sf) following illumination with green 530-nm background light (300 cd m-2, 60 min), and its subsequent recovery in the dark in WT and KO mice either treated (+) or not treated (-) with tamoxifen. WT and KO genotype details are indicated inFigure 5A; WT -tamoxifen: n = 10 eyes, WT +tamoxifen: n = 14 eyes, KO -tamoxifen: n = 12 eyes, KO +tamoxifen: n = 14 eyes. Sfwas normalized to the corresponding dark-adapted value (SfDA) in each case. The time course of light exposure is shown on the bottom. Data are expressed as mean +- SEM (error bars are often smaller than symbol size); significant differences were associated with time point (p < 0.0001) and genotype (p < 0.0001) but not with tamoxifen treatment; three-way repeated measures ANOVA (Table S1).
