Illustration from Scientific Research

Genotypes of mouse lines developed to characterize the contribution of Rgr to cone visual function. Lines carrying Rpe65 and Glast promoter-driven tamoxifen-inducible Cre recombinase transgenes (CreERT2) were used to selectively restore expression of Rgr in the RPE or in Muller glia (MGs), respectively. Schematic heatmap (right) shows anticipated status of Rgr expression before and after the tamoxifen administration.

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